Informatics East and West both used to be fraternity houses. Informatics East used to be called the Beta House, so when it was added as the second Informatics building, I and a few others thought it should have been called "Informatics Beta" (and by extension the original Informatics building would be "Informatics Alpha"), but it never caught on. Now that they've even printed up new signs, I guess that the names "Informatics East" and "Informatics West" are here to stay. They're functional and less confusing, but where's the fun in that?
After this cache had been there awhile, the Informatics department decided to build a third "building" connecting the two existing buildings. I took down the cache during the construction process, but amazingly enough, the hiding spot remained, although you might feel a little more exposed while searching for this than you once did.
Just don't ask any of us what "informatics" is. We don't know either.
When you you have the cache in hand (you'll know because it says "geocache" on it), it just screws open.
Some people find this cache in a few seconds, while others have returned to the spot several times before spotting it. So think of the 2-star difficulty rating as an average. Your mileage may vary.