The church was built in 398, by will of senator Pammachius, over the home of two Roman soldiers, John and Paul, martyred under Julian in 362.
The inside has three naves, with pillars joined to the original columns. The altar is built over a bath, which holds the remains of the two martyrs (John and Paul).
The Passionists are a Roman Catholic religious institute founded by Saint Paul of the Cross with a special emphasis on the Passion of Jesus Christ. Their charism is "We seek the unity of our lives and our apostolate in the Passion of Jesus." The Passionists express their participation in the Passion by a special vow, by which they bind themselves to keep alive the memory of the Passion of Christ. They strive to foster awareness of its meaning and value for each person and for the life of the world. They seek to incorporate this vow into our daily lives by living the evangelical counsels.