You will be visiting two different locations in LoDo. After you find the first location, the next location will be determined using an item at the current location as well as the clues below. The final hide is a nano-cache within 20 feet of the final location which you can locate with the clue.
At the first location use a plaque that details the history of the area to find coordinates by using this code:
North: ACentered centuryDenver's.morecenteredmore
West: moreforcentury Denver'scentered.warehousethandistrict
Then you can head off on foot or by car to the final location. Enjoy!