Genetic Code #5 - Contributions Mystery Cache
Genetic Code #5 - Contributions
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Difficulty:
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Terrain:
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Size: 
(regular)
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Cache is not at the posted coordinates! As a geo-geneticist, you must solve the puzzle below:
Serious efforts to understand how proteins are encoded began after the structure of DNA was discovered by James Watson and Francis Crick, who used the experimental evidence of Maurice Wilkins and Rosalind Franklin, among others. George Gamow postulated that sets of three bases must be employed to encode the 20 standard amino acids used by living cells to build proteins.
The Crick, Brenner et al. experiment first demonstrated that codons consist of three DNA bases; Marshall Nirenberg and Heinrich J. Matthaei were the first to elucidate the nature of a codon in 1961 at the National Institutes of Health. This was followed by experiments in Severo Ochoa's laboratory that demonstrated that the codon AAA specified the amino acid lysine, and the codon CCC specified the amino acid proline. Using different copolymers most of the remaining codons were then determined. Subsequent work by Har Gobind Khorana identified the rest of the genetic code.
Shortly thereafter, Robert W. Holley determined the structure of transfer RNA (tRNA), the adapter molecule that facilitates the process of translating RNA into protein. This work was based upon earlier studies by Severo Ochoa, who worked on the enzymology of RNA synthesis.
For more info see Wikipedia: Genetic Code
Puzzle:
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West |
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Thomas H. Morgan
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Arthur Kornberg
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Francis Crick
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Alexander R. Todd
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George Palade
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James Watson
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Paul Nurse
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Joshua Lederberg
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Robert W. Holley
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Walter Gilbert
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Albrecht Kossel
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Har Gobind Khorana
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François Jacob
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Mario Capecchi
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***Do not forget the Bonus Clue.***
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Additional Hints
(Decrypt)
Pnpur: oruvaq whavcre gehax
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