The Comeback (January 3, 1993, Houston Oilers vs. Buffalo Bills, AFC Wild Card Playoff Game.)
With quarterback Jim Kelly, running back Thurman Thomas, and linebacker Cornelius Bennet out injured, Frank Reich led the Bills back from a 32-point deficit, to defeat the Oilers 41-38 in overtime in a wild card playoff game, the greatest comeback ever in pro football history.
Incidentally, Frank Reich had quarterbacked the University of Maryland team to what was then the greatest comeback in college football history, during a 1984 game versus the University of Miami.