Port Pirie is the sixth most populous city in South Australia after Adelaide, The settlement was founded in 1845 and is the site of the world's largest lead smelter, operated by Nyrstar. It also produces refined silver, zinc, copper and gold.
Prior to European settlement, the location that became Port Pirie was occupied by the indigenous tribe of Nukunu. The location was called 'Tarparrie', which is suspected to mean "Muddy Creek". The first European to see the location was Matthew Flinders in 1802 as he explored the Spencer Gulf by boat. The first land discovery by settlers of the location was by the explorer Edward Eyre who explored regions around Port Augusta. John Horrocks also discovered a pass through the Flinders Ranges to the coast, now named Horrocks Pass.
The town was originally called Samuel's Creek after the discovery of Muddy Creek by Samuel Germein. In 1846, Port Pirie Creek was named by Governor Robe after the John Pirie, the first vessel to navigate the creek when transporting sheep from Bowman's Run near Crystal Brook. In 1848 Matthew Smith and Emanuel Solomon bought 85 acres (34 ha) and subdivided it as a township to be known as Port Pirie. Little development occurred on site and by the late 1860s there were only three woolsheds on the riverfront.
With the discovery of rich silver-, lead- and zinc-bearing ore at Broken Hill in 1883, and the completion of a narrow gauge railway from Port Pirie to close to the Broken Hill field in 1888, the economic activities of the town shifted. In 1889 a lead smelter was built by the British Blocks company to treat Broken Hill ore. The Broken Hill Proprietary initially leased the smelter from British Blocks and then began constructing their own smelter from 1892. In 1915 the smelter was taken over by a major joint venture of Broken Hill-based companies, Broken Hill Associated Smelters (BHAS). Led by the Collins House Group, BHAS became the biggest lead smelter in the world by 1934 processing lead and zinc ore from Broken Hill