Saline County is a county located in the U.S. state of Nebraska. As of the 2010 census, the population was 14,200. Its county seat is Wilber.
In the Nebraska license plate system, Saline County is represented by the prefix 22 (it had the twenty-second-largest number of vehicles registered in the county when the license plate system was established in 1922).
Saline County was formed in 1855 and organized in 1862. The first permanent settler arrived in 1858.