This cache is located just next to Sheffield's Inner Ring Road, so it's definitely not the most scenic or peaceful of locations! The Ring Road was mostly constructed in the 1960s, but this section is actually much newer and is the result of the Sheffield Northern Relief Road scheme which closed a gap in the route. Work began in 1999 and ended finally in 2007. In 2008 this section was renamed Derek Dooley Way in honour of the late Sheffielder who played football for Sheffield Wednesday before breaking his leg and going on to perform a number of backroom roles across the city at Sheffield United.
Also very close to the site of this cache is an elevated section of disused railway track. This used to be part of the Great Central Railway on the route between Chesterfield and Penistone, and Sheffield Victoria Station on this line used to be nearby. You can actually find an excellent cache just down the road cunningly hidden under the bridge which used to support this station (North Sheffield Series - Spider Scare). This line was opened in 1851 but closed on 5th January 1970. However, the trackbed has been preserved for possible future use and in March 2014 a report commissioned by Sheffield City Council even proposed that Sheffield Victoria Station could be used for Sheffield's stop on the proposed HS2 railway line instead of Meadowhall.
The geocache is easily accessible from the path and should be fine for wheelchair users. It's a very busy spot with vehicles constantly thundering past on the Ring Road, but this shouldn't present too much of a problem as the drivers probably won't be interested in what you're doing. Just be careful not to be too conspicious when the nearby traffic lights are at red, and watch out for pedestrian muggles too.
The cache container itself is a small micro with no room for a pen or pencil, so please bring your own. I think it will be a bit tricky to find and it's a little out of the ordinary. Once you have found it, please be careful when replacing it.
Happy caching!