On both side of the road is the Camdeboo National Park and supports a diverse spectrum of wildlife.
Many of the animals show a variety of adaptations to survive in the arid and unstable environment of the Karoo. The springbok is remarkably well-adapted, deriving its water requirements as a by-product of metabolism and seldom, if ever, needs to drink.
The herpetofauna has been well-documented and includes five frog, five tortoise, 19 lizard and 10 snake species.
Four fish species are found within the park.
Forty-three mammal species are found within the park of which 11 are rodents and 13 carnivores.
The crepuscular bat-eared fox is often seen hunting by the use of its large ears to locate insects while the communal behaviour of the suricate (meerkat) can be fascinating to watch.
Vervet monkeys, seen often with tails shortened to varying degree by aggressive interaction within the troop, inhabit the Acacia forests and adjacent plant communities. These primates should never be fed, since this practice subverts their natural behaviour and creates problem animals, which may later have to be destroyed.
Game animals regularly sighted by visitors include steenbok, springbok, blesbok and black wildebeest in open areas. Thicket inhabitants include the kudu and grey duiker which are common as well as the less often seen Cape buffalo. Red hartebeest and gemsbok are frequently observed in the transitional vegetation types. Cape Mountain Zebra may be seen from time to time but prefer the more mountainous areas of the reserve. The klipspringer is well-adapted to the rocky habitats of the park with hooves adapted to enhance their grip on the rocks due to pneumatic spaces in the tips of the hooves.