Otis James McDuffie (born December 2, 1969) is a former American college and professional football player who was a wide receiver in the National Football League (NFL) for eight seasons. He played college football for Penn State University, and earned All-American honors. A first-round pick in the 1993 NFL Draft, he played professionally for the NFL's Miami Dolphins.
The Miami Dolphins selected McDuffie in the first round (25th pick overall) of the 1993 NFL Draft. He returned punts and was a reserve wide receiver before earning the starting spot for the Dolphins. During his formative years with the Dolphins, McDuffie became known as Dan Marino's favorite receiver. His 415 career catches are fourth all-time in Dolphins history. In 1998, McDuffie caught 90 passes, leading the NFL in that category. He is the only Dolphin to achieve this mark. With the exception of Mark Clayton and Mark Duper, McDuffie caught more passes thrown by Dan Marino than any other Miami Dolphin receiver. He played his entire career in Miami, retiring in 2000 because of a nagging toe injury.