This cache is part of an occasional series about Women in STEM (science, technology, engineering and mathematics). The cache is not located at the posted coordinates.
You’ve probably heard of Marie Curie who was the first woman to win the Nobel Prize (in Physics, in 1903), and the only person of any gender to win two Nobel Prizes in different scientific disciplines (she received the award in Chemistry in 1911).
Have you heard of the two women who shared the Nobel Prize in Chemistry in 2020, Emmanuelle Charpentier and Jennifer Doudna? This is the first science Nobel ever won by two women. These scientific collaborators were recognized for their pioneering work in gene editing. Specifically, they developed a method for genome editing that allows scientists to precisely cut any strand of DNA they wish. Prior to the Nobel Prize, their work was recognized with scientific prizes in Biochemistry and Biophysics, Biochemistry and Molecular Biology, Biology, Biopharmaceutical Science, Biotechnology and Medicine, Cancer Research, Chemical Sciences, Genetics, Life Sciences, Medical Sciences, Medicine and Biomedical Research as well as prizes that recognize important scientific contributions.
Jennifer Doudna was born in Washington, DC, grew up in Hilo, Hawaii, studied biochemistry at Pomona College in Claremont, California, and earned a PhD in Biological Chemistry and Molecular Pharmacology from the Harvard Medical School. She currently holds the Li Ka Shing Chancellor’s Professorship in Biomedicine and Health at UC Berkeley and directs the Innovative Genomics Institute.
Emmanuelle Charpentier was born and raised in France, studied biochemistry, microbiology and genetics as an undergraduate, and earned her doctorate from the Institut Pastuer in Paris. She has worked in the United States, Austria, Sweden, and Germany. She is an Honorary Professor at Humboldt University in Berlin and the Founding and Acting Director of the Max Planck Unit for the Science of Pathogens.
Answer these questions to get the coordinates to the cache.
Let A = the number of collaborators who jointly won the Harvey Prize in 2018 ““for leading the development of CRISPR-Cas9 technology, a breakthrough in genetic modification”
Let B = the last digit in the year that Charpentier co-founded CRISPER Therapeutics
Let C = the last digit of the year Charpentier & Doudna earned the Tang Prize in biopharmaceutical science for the discovery of protein tyrosine phosphorylation and tyrosine kinases as oncogenes, leading to successful targeted cancer therapies
Let DD = the last 2 digits in the year they met at a scientific conference plus the last 2 digits in the year they earned the Breakthrough Prize in Life Sciences (for harnessing an ancient mechanism of bacterial immunity into a powerful and general technology for editing genomes, with wide-ranging implications across biology and medicine) plus the last digit in the year they earned the Japan Prize (awarded to people from all parts of the world whose “original and outstanding achievements in science and technology are recognized as having advanced the frontiers of knowledge and served the cause of peace and prosperity for mankind”)
Let EE = the last digit of the year that Doudna earned the Eli Lilly Award in Biological Chemistry plus the last digit of the year that Doudna co-founded Mammoth Biosciences plus the millions of dollars that Mammoth Biosciences received in Series B funding
Let F = the last digit of the year that Charpentier and Doudna were two of the trio who received the Kavli Prize in Nanoscience “for the invention of CRISPR-Cas9, a precise nanotool for editing DNA, causing a revolution in biology, agriculture and medicine”
Let GG = the last two digits in the year that Doudna & Charpentier received the Princess of Asturias Award for Technical and Scientific Research, specifically for scientific advances that have led to the development of a technology that allows genes to be modified with great precision and simplicity in all types of cells
The cache can be found at N45 AB.CDD W122 EE.FGG