Missaukee County is a county located in Michigan. As of the 2020 Census, the population was 15,052. The county seat is Lake City.

Missaukee County was partitioned from Mackinac County, on April 1, 1840, due to expected population growth. In 1851, the county was attached to Grand Traverse County for legal purposes. It was subsequently attached to Manistee County in 1855 and Wexford County in 1869, before being organized in its own right in 1871.
Missaukee County may be named after a prominent Ottawa chief, Nesaukee, who signed the treaties of 1831 and 1833. However, it is also said that "Nesaukee" could be interpreted as 'large mouth of the river.'
According to the U.S. Census Bureau, the county has a total area of 574 square miles, of which 565 square miles is land and 9.1 square miles (1.6%) is water.