Maysfield was originally called Old Graball; however, it eventually adopted the name Maysfield in tribute to Thomas Newton Mayes, a resident of the region since 1853. In 1868, the Maysfield post office was founded. A Presbyterian church was established in 1873, with two presiding elders and nine members. The church had 90 members in 1884; meetings were held in members' houses until a church building was built ten years later. Maysfield had 250 people, a steam gristmill, and a cotton gin in 1884 as well. The community was situated between Calvert and Cameron on the stage. As many as four distinct railroad corporations intended to build tracks from Calvert or Hearne through Maysfield to Cameron and eastward into Bell County between the 1860s and the 1890s