A quick two-part multi-cache. Yes, it is wheelchair accessible.
A website presents information about Highway 40 in California. It begins by mentioning, "Old U.S. Highway 40 stretches from New Jersey to California, and with Route 66, was one of the main travel routes across the country. To travel today on Old Highway 40 instead of Interstate 80 is to see America as it once was."
US 40 passes through Reno along Fourth Street. Interstate-80 replaced US 40 as the main route through Reno in 1972–1974. The city has seen major changes since the arrival of the Interstate. Of note, the interstate exits, especially Exit 13, serving Sierra and Virginia Streets in downtown, prompted small economic booms on adjacent properties. Those booms included the building of the large hotel-casino resorts of downtown Reno, and the consequential, but not instant, fading away of multiple smaller lodging facilities along US 40. Fourth Street was previously lined with many small motels. The development of large resorts and the demolition of small motels continues today.
In the days when the motels ran the length of Fourth Street, from the Pony Express Lodge in Sparks, west to the outskirts of Reno near McCarran Boulevard, Fourth Street provided the greater part of the lodging, and Virginia Street the gaming, for out-of-town visitors.
Here's a link to a more extensive description with details about some of the past and present changes.
And, oh, while you are at it hunting for the cache, take a minute to enjoy the Neon Highway 40 sign west of the posted coordinates.
This cache calls for stealth. Please use stealth and please log your DNFs.