From 1876 to 1881 he studied medicine at the University of Edinburgh, including a period working in the town of Aston (now a district of Birmingham). While studying, he also began writing short stories; his first published story appeared in Chambers's Edinburgh Journal before he was 20. Following his term at university, he served as a ship's doctor on a voyage to the West African coast. He completed his doctorate on the subject of tabes dorsalis in 1885.
In 1882, he joined former classmate George Budd as his partner at a medical practice in Plymouth, but their relationship proved difficult, and Conan Doyle soon left to set up an independent practice. Arriving in Portsmouth in June of that year with less than £10 to his name, he set up a medical practice at 1 Bush Villas in Elm Grove, Southsea. The practice was initially not very successful; while waiting for patients, he again began writing stories. His first significant work was A Study in Scarlet, which appeared in Beeton's Christmas Annual for 1887 and featured the first appearance of Sherlock Holmes, who was partially modelled after his former university professor, Joseph Bell. Future short stories featuring Sherlock Holmes were published in the English Strand Magazine. Interestingly, Rudyard Kipling congratulated Conan Doyle on his success, asking "Could this be my old friend, Dr. Joe?" Sherlock Holmes, however, was even more closely modelled after the famous Edgar Allan Poe character, C. Auguste Dupin.
In 1890, Conan Doyle studied the eye in Vienna; he moved to London in 1891 to set up a practice as an ophthalmologist. He wrote in his autobiography that not a single patient crossed his door. This gave him more time for writing, and in November 1891 he wrote to his mother: "I think of slaying Holmes... and winding him up for good and all. He takes my mind from better things." His mother responded, saying, "You may do what you deem fit, but the crowds will not take this lightheartedly." In December 1893, he did so in order to dedicate more of his time to more "important" works.
Holmes and Moriarty apparently plunged to their deaths together down a waterfall in the story, "The Final Problem". Public outcry led him to bring the character back; Conan Doyle returned to the story in "The Adventure of the Empty House", with the explanation that only Moriarty had fallen but, since Holmes had other dangerous enemies, he had arranged to be temporarily "dead" also. Holmes ultimately appears in a total of 56 short stories and four Conan Doyle novels.
In 1902, Arthur Conan Doyle was knighted and appointed Deputy-Lieutenant of Surrey.
Richard Milner, an American historian of science, has presented a case that Conan Doyle may have been the perpetrator of the Piltdown Man hoax of 1912, creating the counterfeit hominid fossil that fooled the scientific world for over 40 years. Milner says that Conan Doyle had a motive, namely revenge on the scientific establishment for debunking one of his favorite psychics, and that The Lost World contains several encrypted clues regarding his involvement in the hoax.
Conan Doyle was found clutching his chest in the family garden at "Windlesham", Crowborough, on 7 July 1930. He soon died of his heart attack, aged 71, and is buried in the Church Yard at Minstead in the New Forest, Hampshire, England. His last words were directed toward his wife: "You are wonderful." The epitaph on his gravestone reads:
| STEEL TRUE |
| BLADE STRAIGHT |
| ARTHUR CONAN DOYLE |
| KNIGHT |
| PATRIOT, PHYSICIAN & MAN OF LETTERS |
Later, in 2008, many of his works were idolized in the caching community in parodies written by TeamOxford. The bookmark to these amazing stories can be found here:The Game is a foot! TeamOxford's New Adventures of Sherlock Holmes . In honor of all the hard work and effort to bring these stories alive, we placed this preform container in the Forbis Cemetery near Conan Doyle. Conan Doyle is not the closest marker to the cache, but he is right next to the one that is.