What a Rush! Mystery Cache

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Endorphins ("endogenous morphine") are endogenous opioid peptides that function as neurotransmitters. They are produced by the pituitary gland and the hypothalamus in vertebrates during exercise, excitement, pain, consumption of spicy food, love and orgasm, and they resemble the opiates in their abilities to produce analgesia and a feeling of well-being.

The term "endorphin rush" has been adopted in popular speech to refer to feelings of exhilaration brought on by pain, danger, or other forms of stress, supposedly due to the influence of endorphins. When a nerve impulse reaches the spinal cord, endorphins that prevent nerve cells from releasing more pain signals are released.

A publicized effect of endorphin production is the so-called "runner's high", which is said to occur when strenuous exercise takes a person over a threshold that activates endorphin production. Endorphins are released during long, continuous workouts, when the level of intensity is between moderate and high, and breathing is difficult. This also corresponds with the time that muscles use up their stored glycogen. During a release of endorphins, the person may be exposed to bodily harm from strenuous bodily functions after going past his or her body's physical limit. This means that runners can keep running despite pain, continuously surpassing what they otherwise would consider to be their limit. Runner's high has also been known to create feelings of euphoria and happiness.

Runner's high has been suggested to have evolutionary roots based on the theory that it helped with the survival of early humans. Runner's high allows humans to run for vast lengths without pain. Most early humans hunted and gathered for their food. This required them to cover long distances hunting down their prey or foraging for their food. This could have caused them to develop conditions such as shin splints and stress fractures in their shin and feet bones. Without runner's high to negate the pain caused by running on bones with these conditions, early humans theoretically would not have been able to repeatedly cover these vast distances in search of their food and thus would have starved. Current African tribes make use of runner's high when conducting persistence hunting (a method in which tribesman hunt an animal and track it for miles, eventually killing the animal due to its vulnerability brought on by exhaustion).

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