According to Wikipedia and other sources, on July 22nd:
1587 – Colony of Roanoke: a second group of English settlers arrives on Roanoke Island off North Carolina to re-establish the deserted colony.
1796 – Surveyors of the Connecticut Land Company name an area in Ohio "Cleveland" after Gen. Moses Cleaveland, the superintendent of the surveying party.
1894 – The first ever motor race is held in France between the cities of Paris and Rouen.
1934 – Outside Chicago's Biograph Theater, "Public Enemy No. 1" John Dillinger is mortally wounded by FBI agents.
2012 - Ron Santo of the Chicago Cubs is posthumously inducted into the Baseball Hall of Fame.