Nuckolls County was formed in 1860. It was named after Stephen F. Nockolls, an early pioneer in this area.
In 1887, Atchison, Topeka and Santa Fe Railway built a branch line from Neva (3 miles west of Strong City) to Superior, Nebraska. This branch line connected Strong City, Neva, Rockland, Diamond Springs, Burdick, Lost Springs, Jacobs, Hope, Navarre, Enterprise, Abilene, Talmage, Manchester, Longford, Oak Hill, Miltonvale, Aurora, Huscher, Concordia, Kackley, Courtland, Webber, Superior. At some pint, the line from Neva to Lost Springs was pulled but the right of way has not been abandoned. This branch line was originally called "Strong City and Superior line" but late the name was shortened to the "Strong City line". In 1996, the Atchison, Topeka and Santa Fe Railway merged with Burlington Northern Railroad and renamed to the current BNSF Railway. Most locals still refer to this railroad as the "Santa Fe".