The Hognose snake's most distinguishing feature is the upturned snout, used for digging in sandy soils.
The color pattern is extremely variable. It can be red, green, orange, brown, gray to black, or any combination thereof depending on locality. In this species the underside of the tail is lighter than the belly. Although H. platyrhinos is rear-fanged, it is often considered nonvenomous because it is not harmful to humans. Heterodon means "different tooth", which refers to the enlarged teeth at the rear of the upper jaw. These teeth inject a mild amphibian-specific venom into prey, and also are used to "pop" inflated toads like a balloon to enable swallowing.